Negin Rezavand; Somayeh Darvishi; Maryam Hematti; Mansour Rezaei; Houshang Nemati; Seyed Mohammad Saleh Seyedzadeh; Alireza Kamravamanesh; Saydeh Saba Seyedzadeh; Mastaneh Kamravamanesh
Abstract
Background: Endocrine disorders, such as hypothyroidism, can impact fetal growth and development. The significance and necessity of fetal screening before birth are critical for the prevention of congenital disabilities. The present study aimed to evaluate the association between thyroid hormones, specifically ...
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Background: Endocrine disorders, such as hypothyroidism, can impact fetal growth and development. The significance and necessity of fetal screening before birth are critical for the prevention of congenital disabilities. The present study aimed to evaluate the association between thyroid hormones, specifically T3, T4, FT3, FT4, TSH, Anti TPO, Free BhCG, B-MOM, P-MOM, and NT-MOM, and the risk of screening tests conducted during the first trimester of pregnancy in women diagnosed with hypothyroidism.Methods: This retrospective, case-control study included 82 pregnant women in their first trimester who were referred for fetal screening tests between 2022 and 2023 at Imam Reza and Motazadi hospitals in Kermanshah, Iran. The case group consisted of 41 pregnant women diagnosed with hypothyroidism and treated with levothyroxine, and the control group comprised 41 pregnant women with normal thyroid function. The assessment of serum levels of T3, free T3, T4, free T4, TSH, and Anti TPO was carried out using the ELISA method, while the first-stage fetal screening tests, including Free BhCG, B-MOM, P-MOM, and NT-MOM, were conducted using the Electro-chemiluminescent (ECL) method. Subsequently, data analysis was conducted using SPSS.Results: In the case group, the average levels of TSH (P=0.001), TPO (P=0.006), trisomy 21 (P=0.001), and trisomy 13/18 (P=0.001) were significantly higher as compared with the control group. Conversely, in the case group, PAPP-A was significantly lower (P=0.001). However, there was no statistically significant difference between the two groups in terms of mean levels of beta-hCG (P=0.297), B-MoM (P=0.202), and NT-MoM (P=0.221). Furthermore, in the case group treated with levothyroxine, mean serum TSH level was significantly higher in the screen positive and medium risk groups of Down syndrome (DS) as compared with the negative screen group (P=0.014).Conclusion: Our results indicated that it is important to promptly identify pregnant women with hypothyroidism and ensure that timely screening tests for fetal health are carried out as a mandatory practice.
Shalaleh Aghaei; Roghaye Mohammadirad; Azita Fathnezhad-Kazemi
Abstract
Introduction: There is scarce information about the effects of SARS‐CoV‐2 infection in pregnant women. The present study aimed to evaluate pregnancy’s clinical characteristics and outcomes in women with COVID-19 and their babies.Case Presentation: We conducted a case series study, from April ...
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Introduction: There is scarce information about the effects of SARS‐CoV‐2 infection in pregnant women. The present study aimed to evaluate pregnancy’s clinical characteristics and outcomes in women with COVID-19 and their babies.Case Presentation: We conducted a case series study, from April 15 to May 30, 2021, including 24 cases with COVID-19 infection and their babies with a 30-day follow-up after delivery. The patients’ mean (SD) age of was 31.50 (5.69) years, and all the deliveries were in the third trimester. Fever and myalgia were the most prevalent clinical symptoms in women. Positive RTPCR test results [in 20 pateints (83.33%)], and CT scan findings [in four patients (16.67%)] confirmed the diagnosis. Moreover, 66.66% of pregnant women with COVID-19 underwent Cesarean section. Performing a Cesarean section was mostly due to obstetric indications or the mother’s request. None of the babies were positive PCR. Out of eight preterm infants, seven were admitted to the intensive care unit (NICU) for reasons other than COVID-19.Conclusion: The most common obstetric outcomes were high rates of premature delivery and Cesarean section. Additionally, the most prevalent neonatal consequences were prematurity and low birth weight. There was; however, no evidence of intrauterine vertical transmission.
