Mahmood Soveid; Nasrin Asadi; Mahnoosh Sianati
Abstract
Background: There is biologic and clinical evidence that links vitamin D deficiency to pre-eclampsia. The Vitamin D receptor is present in the placenta, cardiovascular system, and lymphocytes. It has anti-inflammatory, immune regulatory, and anti-hypertensive properties and facilitates placental implantation. ...
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Background: There is biologic and clinical evidence that links vitamin D deficiency to pre-eclampsia. The Vitamin D receptor is present in the placenta, cardiovascular system, and lymphocytes. It has anti-inflammatory, immune regulatory, and anti-hypertensive properties and facilitates placental implantation. Each of these processes is involved in the pathogenesis of pre-eclampsia.
Objectives: The main purpose of this study was to study the relationship between vitamin D deficiency and severe pre-eclampsia in a population residing in southern Iran that is generally known to have a high prevalence of vitamin deficiency. As a second objective, the prevalence of vitamin D deficiency in pregnant women was investigated.
Patients and Methods: We conducted a case-control study of 59 patients with severe preeclampsia and 217 controls, all of whom were from southern Iran. Cases and controls were matched for age, body mass index, and gestational age. The study was carried out in autumn and winter. Plasma 25-hydroxyvitamin D was measured using high performance liquid chromatography, and the results were compared between the two groups.
Results: Almost all controls and patients had 25-hydroxyvitamin D levels below normal, and 69% had levels below 10 ng/mL. The mean 25-hydroxyvitamin D levels in the patient and control groups were 8.4 (6.2) and 8.5 (6.9) ng/ml (P = 0.80), respectively. The level of 25-hydroxyvitamin D had no significant association with subjects’ body mass index or age.
Conclusions: Pregnant women in our region have a high prevalence of vitamin D deficiency, and in a population with severe vitamin D deficiency, there is no significant correlation between 25-hydroxyvitamin D levels and preeclampsia. Severe deficiency masks any possible association in a case-control study. Controlled trials with vitamin D supplementation are recommended for further studies.
Bahia Namavar Jahromi; Rosyna Adibi; Sadaf Adibi; Leila Salarian
Abstract
Background: Preeclampsia is a unique idiopathic syndrome in human pregnancy that can involve almost all organ systems.
Objectives: The aim of the present study was to compare the periodontal diseases between the preeclamptic and normal pregnant women in order to find a possible risk factor relationship.
Materials ...
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Background: Preeclampsia is a unique idiopathic syndrome in human pregnancy that can involve almost all organ systems.
Objectives: The aim of the present study was to compare the periodontal diseases between the preeclamptic and normal pregnant women in order to find a possible risk factor relationship.
Materials and Methods: This case-control study was performed on 200 pregnant women, with maternal age ≤ 35 years and gestational age ˃ 20 weeks with singleton pregnancies. Of these, 100 women were preeclamptic with proteinuria and blood pressure ≥ 140/90 and 100 women with normal blood pressure in the control group. Oral examination was performed on all women by a dentist for detection of periodontal diseases. Gingivitis and periodontitis were diagnosed based on the American Academy of Periodontology (AAP)/American Dental Association (ADA) classification, using the measurement method of Ramfjord. The preeclamptic women were then sub-classified into mild and moderate and comparisons were made between all groups.
Results: The mean maternal age, BMI, neonatal birth weights and gestational age at delivery were not significantly different between the preeclamptic and normal groups. There was a significant association between preeclampsia and periodontal diseases (P ˂ 0.01). The mean number of involved teeth (P ˂ 0.001) and the mean pocket depth (P = 0.04) were higher among the preeclamptic group. Gingivitis was more frequent among the cases with mild (56.8%) compared to (31.6%) in the severe preeclamptic group (P = 0.04). Periodontitis was more prevalent among the cases with severe preeclampsia which was not statistically significant. The mean neonatal birth weight was significantly lower in the group with severe preeclampsia (P < 0.01).
Conclusions: There was a significant association between preeclampsia and periodontal diseases. The number of involved teeth and pocket depth were higher among the preeclamptic mothers compared to normal pregnant women.
