Masoumeh Gholaman; Mandana Gholami; Mohammad Ali Azarbayjani; Hossein Abed Natanzi
Abstract
Background: Galectin-3 and pentraxin-3 are recognized as cardiovascular risk factors, levels of which change in the pathological conditions, including type 2 diabetes. The aim of present research was to investigate the high and moderate intensity aerobic training effects on galectin-3, pentraxin-3, and ...
Read More
Background: Galectin-3 and pentraxin-3 are recognized as cardiovascular risk factors, levels of which change in the pathological conditions, including type 2 diabetes. The aim of present research was to investigate the high and moderate intensity aerobic training effects on galectin-3, pentraxin-3, and some inflammatory mediators levels in type 2 diabetic women. Methods: Our study was a randomized clinical trial, conducted on the 36 type 2 diabetic women with an average age of 46.95±3.49 years old, randomly assigned to three equal groups, including control, continuous training with moderate-intensity (MICT), and high intensity interval training (HIIT) groups. Both MICT and HIIT program performed three sessions per week over a 12-week period. Training intensity in HIIT and MICT group was 90 and 60-70 percent of maximum heart rate, respectively. Blood samples at the baseline and after the 12-week training intervention were collected and the variables levels were measured via ELISA method. Repeated measures ANOVA test and Tukey post-hoc test were employed for data analysis. The research is documented in the Iranian Registry of Clinical Trials (registration number: IRCT20200729048252N1). Results: Galectin-3 levels significantly decreased in HIIT and MICT groups (p <0.001). However, no significant differences were observed for Pentraxin-3 levels between different group (P=0.306), yet paired t test indicated that Pentraxin-3 levels significantly decreased in HIIT group (P=0.003). In addition, serum levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) significantly declined in HIIT and MICT groups (p <0.05). Conclusion: HIIT and MICT intervention results in a significant decrease in inflammatory mediators and HIIT protocol was not superior to MICT protocol for observed changes in inflammatory mediators.
soheila Rahmani; Mohsen Mansoobifar; Mohammad Reza Sirifi; Hasan Ashayeri; Hamed Bermas
Abstract
Background: Diabetes can be successfully controlled by metabolic, psychological, social, and interpersonal factors. The present study aimed to determine the effectiveness of family empowerment therapy based on self-compassion on self-care and glycosylated hemoglobin in female patients with type 2 diabetes ...
Read More
Background: Diabetes can be successfully controlled by metabolic, psychological, social, and interpersonal factors. The present study aimed to determine the effectiveness of family empowerment therapy based on self-compassion on self-care and glycosylated hemoglobin in female patients with type 2 diabetes mellitus. Methods: In a randomized controlled clinical trial with control group, pre-test, and post-test, 60 women with type 2 diabetes referred to the endocrinology department of Imam Hossein Hospital in Tehran province from December 2018 to April 2019 were randomly selected from the 73 patients narrowed down according to the inclusion criteria. Afterwards, they were randomly assigned to experimental and control groups. The experimental group (n=30) was treated with family empowerment therapy based on self-compassion for eight weekly 90-minute sessions while the control group (n=30) received usual hospital treatments. Data collection instrument was Summary of Diabetes Self-Care Activities; glycosylated hemoglobin measurements were performed in three phases of baseline, after intervention, and three-month follow-up and analyzed by multivariate repeated measures analysis of variance and Bonfroni post-hoc test using the SPSS-21 software. Results: The results of repeated measures analysis of variance showed significant differences after the intervention between the experimental and control groups regarding self-care (P0.001=, F=561.086) and glycosylated hemoglobin (P=0.001, F=304.953); furthermore, comparison of the means indicated the effectiveness of the treatment in improving self-care and reducing glycosylated hemoglobin levels in the experimental group compared to the control group. Moreover, the Bonferroni test results showed that in the pretest stage, there was no significant difference between the two groups in terms of self-care (P=0.447) and glycosylated hemoglobin (P=0.887); however, in the post-test and follow-up stages, the two groups showed were significantly different concerning self-care (P=0.001) and glycosylated hemoglobin (P=0.001), implying the effectiveness of the intervention and the sustainability of its effects. Conclusions: The results of the present study revealed that family empowerment therapy based on self-compassion can be effective in improving self-care and reducing glycosylated hemoglobin in women with type 2 diabetes.
