Document Type : Research Article


1 Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Department of Physical Education and Sport Sciences, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran



Background: Exercise training and omega-3 supplementation are believed to have a positive effect on obese and overweight people. We conducted the present study in order to investigate the effect of aerobic training and omega3 ingestion on the levels of Adipsin and insulin resistance in overweight and obese women.
Methods: In this semi-experimental study conducted in Tehran, summer 2020, 40 overweight and obese women (aged from 20 to 35 years old, and BMI 29.6±1.93 kg.m2) were assigned in four equal groups, namely placebo (P), omega-3 (O), training (E), and training+omega-3 (OE) groups. The subjects in the training and training+omega-3 groups completed the eight-week (three sessions per week) aerobic training program. 2000 mg omega-3 supplement was consumed on a daily basis. Blood samples were obtained before and after completing the intervention and Adipsin and insulin levels were measured. The data were analyzed via repeated measures analysis of variance (ANOVA) test along with Tukey post-hoc test. The study was approved under the IRCT registration code of IRCT20200811048360N1.
Results: The findings of the present research shed light on a significant decrease in serum Adipsin levels in the E and OE groups compared to those in the P and O groups (p <0.05). Moreover, insulin resistance significantly decreased in E compared with that in the P group (P=0.012) and also in the OE group compared to that in the P (P=0.001) and O (P=0.009) groups.
Conclusion: The present study indicated that omega-3 supplementation could increase the effect of exercise training on the reduction in the Adipsin and insulin resistance; further effects may be observed by increasing the duration of exercise training period.