Document Type : Case Report


1 Infectious and Tropical Diseases Unit, “Annunziata” Hospital, Azienda Ospedaliera di Cosenza, Cosenza, Italy

2 Microbiology and Virology Unit, “Annunziata” Hospital, Azienda Ospedaliera di Cosenza, Cosenza, Italy

3 Hospital Pharmacy, “Annunziata” Hospital, Azienda Ospedaliera di Cosenza, Cosenza, Italy


Introduction: The Covid-19 pandemic has so far been characterized by significant morbidity and a high mortality rate worldwide. People who are frail due to age and / or the presence of comorbidities, including pregnant women, are exposed to a greater risk of developing a very serious disease. However, only recently, certain experimental studies have focused on the role of anti- Covid-19 drugs during pregnancy. Convalescent plasma (CP), derived from the people who recover from Covid-19, can represent an interesting therapeutic option for improving the antiviral immune response, owing to its specific neutralizing content and different immune mediators against SarsCov-2. It can also improve the survival of the patients who are diagnosed with the disease early and treated in the primary stages of the disease.
Case Presentation: We reported the case of a pregnant patient safely treated with CP at our hospital and conducted a comprehensive literature search using extensive database for similar case reports published from February 12, 2020 to May 31, 2021.
Conclusions: An extensive literature search documented the publication of a limited number of case reports concerning Covid-19 hyperimmune plasma treatment (CPT) during pregnancy. The available results are not homogeneous; however, a very early use of CPT may possibly be effective in pregnancy. The evolution of Covid-19-related pneumonia, due to a reduction in both viremia and the concentration of proinflammatory cytokines, can be positively influenced by CPT, together with the standards of care treatment.


1. Bhimraj A, Morgan RL, Shumaker AH, Shumaker AH, Lavergne V, Baden L, et al. Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19. Clin Infect Dis. 2020;ciaa478. doi: 10.1093/cid/ciaa478. PubMed PMID: 32338708; PubMed Central PMCID: PMC7197612. ## 2.Kong L. Severe acute respiratory syndrome (SARS). Transfus Apher Sci. 2003;29(1):101. doi: 10.1016/s1473-0502(03)00109-5. PubMed PMID: 12952008; PubMed Central PMCID: PMC7128968. ## 3.van Griensven J, Edwards T, Gallian P; Consortium E. Convalescent Plasma for Ebola Virus Disease. N Engl J Med. 2016;374(25):2500. doi: 10.1056/NEJMc1602284. PubMed PMID: 27332913. ## 4. Beigel JH, Tebas P, Elie-Turenne MC, Bajwa E, Bell TE, Cairns CB, et al. Immune plasma for the treatment of severe influenza: an open-label, multicentre, phase 2 randomised study. Lancet Respir Med. 2017;5(6):500-511. doi: 10.1016/S2213-2600(17)30174-1. PubMed PMID: 28522352; PubMed Central PMCID: PMC5828518. ## 5 Grisolia G, Franchini M, Glingani C, Inglese F, Garuti M, Beccaria M, et al. Convalescent plasma for coronavirus disease 2019 in pregnancy: a case report and review. Am J Obstet Gynecol MFM. 2020;2(3):100174. doi: 10.1016/j.ajogmf.2020.100174. PubMed PMID: 32838270; PubMed Central PMCID: PMC7332432. ## 6. Soleimani Z, Soleimani A. ADRS due to COVID-19 in midterm pregnancy: successful management with plasma transfusion and corticosteroids. J Matern Fetal Neonatal Med. 2020;1-4. doi: 10.1080/14767058.2020.1797669. PubMed PMID: 32715804. ## 7. Jacobson J, Antony K, Beninati M, Alward W, Hoppe KK. Use of dexamethasone, remdesivir, convalescent plasma and prone positioning in the treatment of severe COVID-19 infection in pregnancy: A case report. Case Rep Womens Health. 2021;29:e00273. doi: 10.1016/j.crwh.2020.e00273. PubMed PMID: 33262932; PubMed Central PMCID: PMC7687655. ## 8. Piechotta V, Iannizzi C, Chai KL, Valk SJ, Kimber C, Dorando E, et al. Convalescent plasma or hyperimmune immunoglobulin for people with COVID-19: a living systematic review. Cochrane Database Syst Rev. 2021;5(5):CD013600. doi: 10.1002/14651858.CD013600.pub4. PubMed PMID: 34013969; PubMed Central PMCID: PMC8135693. ## 9. Libster R, Pérez Marc G, Wappner D, Coviello S, Bianchi A, Braem V, et al. Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults. N Engl J Med. 2021;384(7):610-618. doi: 10.1056/NEJMoa2033700. PubMed PMID: 33406353; PubMed Central PMCID: PMC7793608. ## 10. Joyner MJ, Bruno KA, Klassen SA, Kunze KL, Johnson PW, Lesser ER, et al. Safety Update: COVID-19 Convalescent Plasma in 20,000 Hospitalized Patients. Mayo Clin Proc. 2020;95(9):1888-1897. doi: 10.1016/j.mayocp.2020.06.028. PubMed PMID: 32861333; PubMed Central PMCID: PMC7368917. ##