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The Effect of Aerobic-resistance Training and Caloric Restriction on Hepatokine Factors Alterations in Obese Women with Non-alcoholic Fatty Liver Disease

Document Type : Research Article

Authors

Department of Exercise Physiology, Il.C., Islamic Azad University, Ilam, Iran

Abstract

Background: Factors secreted from hepatocytes, such as hepatokines, play a role in regulating intra and extrahepatic metabolic processes. The aim of this study was to investigate the effect of combined aerobic-resistance training (CT) and calorie restriction (CR) on hepatokines alteration in women with non-alcoholic fatty liver (NAFL) disease.
Methods: This quasi-experimental study was carried out using a pretest-posttest design in Ilam, Iran during the spring of 2023. A convenience sample of 37 participants was selected and randomly divided to one of four groups: control, CR, CT and CR+CT. The CT program was performed for eight weeks and three sessions per week. The CR groups, alleviate 400- 500 kcal/day from total daily calorie intake. Fatty liver was measured by ultrasound. Serum level of leukocyte-derived chemotaxin 2 (LECT2), angiopoietin-dependent growth factor (AGF) and sex hormone-binding globulin (SHBG) were measured in pre- and postintervention. Analysis of covariance (ANCOVA) and Bonferroni post hoc test were used to analyze between-group alterations.
Results: After CT and CR+CT, LECT2 (P=0.011, P=0.006, respectively) and AGF (P=0.041, P=0.032, respectively) level significantly decreased than the control group, and in CR group decreased compared with the pre-intervention (P=0.037, P=0.018, respectively). Also, SHBG level in the CT and CR+CT groups significantly increased than the control group (P=0.013, P=0.006, respectively), and in CR group increased than the pre-intervention (P=0.004).
Conclusions: CR has limited effects on the level of hepatokines in obese women with NAFL disease. In order to create favorable alterations in the level of hepatokines, this intervention should be implemented with CT.

Highlights

Abdolhossein Taheri Kalani: (Google Scholar)

 

How to Cite: Hayati M, Fatahi F, Taheri Kalani A. The Effect of Aerobic-resistance Training and Caloric Restriction on Hepatokine Factors Alterations in Obese Women with Non-alcoholic Fatty Liver Disease. Women. Health. Bull. 2025;12(3):170-179. doi: 10.30476/whb.2025.105828.1337.

Keywords

References
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Women’s Health Bulletin
Volume 12, Issue 3 - Serial Number 46
July 2025
Pages 170-179
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