Mitra Hayati; Fardin Fatahi; Abdolhossein Taheri Kalani
Abstract
Background: Factors secreted from hepatocytes, such as hepatokines, play a role in regulating intra and extrahepatic metabolic processes. The aim of this study was to investigate the effect of combined aerobic-resistance training (CT) and calorie restriction (CR) on hepatokines alteration in women with ...
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Background: Factors secreted from hepatocytes, such as hepatokines, play a role in regulating intra and extrahepatic metabolic processes. The aim of this study was to investigate the effect of combined aerobic-resistance training (CT) and calorie restriction (CR) on hepatokines alteration in women with non-alcoholic fatty liver (NAFL) disease.Methods: This quasi-experimental study was carried out using a pretest-posttest design in Ilam, Iran during the spring of 2023. A convenience sample of 37 participants was selected and randomly divided to one of four groups: control, CR, CT and CR+CT. The CT program was performed for eight weeks and three sessions per week. The CR groups, alleviate 400- 500 kcal/day from total daily calorie intake. Fatty liver was measured by ultrasound. Serum level of leukocyte-derived chemotaxin 2 (LECT2), angiopoietin-dependent growth factor (AGF) and sex hormone-binding globulin (SHBG) were measured in pre- and postintervention. Analysis of covariance (ANCOVA) and Bonferroni post hoc test were used to analyze between-group alterations.Results: After CT and CR+CT, LECT2 (P=0.011, P=0.006, respectively) and AGF (P=0.041, P=0.032, respectively) level significantly decreased than the control group, and in CR group decreased compared with the pre-intervention (P=0.037, P=0.018, respectively). Also, SHBG level in the CT and CR+CT groups significantly increased than the control group (P=0.013, P=0.006, respectively), and in CR group increased than the pre-intervention (P=0.004).Conclusions: CR has limited effects on the level of hepatokines in obese women with NAFL disease. In order to create favorable alterations in the level of hepatokines, this intervention should be implemented with CT.
Hadis Feyzi; Mahnaz Omidi; Abdolhossein Taheri Kalani
Abstract
Background: Obesity and being overweight elevate triglycerides, blood cholesterol, blood pressure, and LDL levels while decreasing HDL levels. This study aimed to examine the impact of eight weeks of interval training combined with melatonin consumption on novel obesity indicators and the atherogenic ...
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Background: Obesity and being overweight elevate triglycerides, blood cholesterol, blood pressure, and LDL levels while decreasing HDL levels. This study aimed to examine the impact of eight weeks of interval training combined with melatonin consumption on novel obesity indicators and the atherogenic index in overweight and obese women.Methods: This semi-experimental, applied research involved 40 women aged between 30 to 45 years. They were randomly divided into four groups of ten each: intense interval training plus melatonin consumption (Group I), intense interval training plus placebo (Group II), melatonin consumption only (Group III), and a control group. The high-intensity interval training was conducted over eight weeks, with three sessions weekly. The regimen progressed from 5 repetitions in the first and second weeks to 6 in the third and fourth weeks, 7 in the fifth and sixth weeks, and 8 in the final two weeks. Groups I and III consumed 3 mg of melatonin tablets (manufactured by Razak company, Iran) nightly, an hour before bedtime, for the study duration. Data were analyzed using SPSS version 22 at 0.05 significance level.Results: The combination of eight weeks of interval training and melatonin consumption significantly impacted the visceral adiposity index (VAI), atherogenic plasma index (AIP), TC/HDL-c ratio, and HDL-c levels in overweight and obese women (P=0.001 for each). However, there were no significant effects on the ApoA-1/ApoB ratio, body adiposity index (BAI), or ApoA- 1 and Apo B levels (P=0.089, P=0.053, P=0.696, P=0.156, respectively).Conclusion: Intensive interval training coupled with melatonin supplementation positively influences obesity management, weight control, and cardiovascular disease risk reduction in overweight and obese women.
